Protein memory research papers


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A pathway for conformational diversity in proteins mediated by intramolecular chaperones
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 Point mutations within IMCs alter folding, resulting in structural conformers that specifically interact with their cognate IMCs in a process termed protein memory. Here, we show a mechanism that mediates conformational diversity in subtilisin. 

Biomolecular electronics: protein-based associative processors and volumetric memories
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 irradiated volume elements. The methods and procedures of prototyping these bioelectronic devices are discussed. We also examine current efforts to optimize the protein memory medium by using chemical and genetic methods. 

Future memory storage technology: protein-based memory devices may facilitate surpassing Moore's law
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Lipid-assisted protein folding
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 prior to the involvement of PE. A similar concept of protein memory was used to describe the action of intramolecular chaperones represented by the propeptides of some proteases (50). Subtilisin and a-lytic protease purified 

Efficient algorithms for protein-based associative processors and volumetric memories
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devices. In addition, bacteriorhodopsin protein memory devices exhibit increased thermal, chemical and photochromic stability, and have the advantage of being portable, radiation-hardened, waterproof, and EMP-resistant. 

Chaperoning Anfinsen: the steric foldases
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 Moreover, subtilisin exemplifies a striking case of 'protein memory' of the protease and emphasizes that steric information is 'imprinted' upon the protease by the propeptide.  Protein memory through altered folding mediated by intramolecular chaperones.

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
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The cAMP-responsive element-binding protein (WEB) has been implicated in the activation of protein synthesis required for long-term facilitation, a cellular model of memory in Aplysia. Our studies with fear conditioning and with the water maze show that mice with a targeted

Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory
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Involvement of the CAMP cascade in Drosophila learning and memory is suggested by the aberrant behavioral phenotypes of the mutants dunce (CAMP phosphodiesterase) and rutabaga (adenylyl cyclase). line DCo5 isolated via an enhancer detector screen for

Prion proteins as memory molecules: an hypothesis
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of which the prion proteins involvement in memory is but one example (oil 5 847 857. Shinde UP. Liu J. .1. and lnouye M. (1997) Protein memory through altered lolding mediated by intramolecular chaperones. Nature 38 520 7522. Stahl l\1 Baldwin MA, Teplow DB

Insulin effects on glucose metabolism, memory , and plasma amyloid precursor protein in Alzheimers disease differ according to apolipoprotein‐E genotype
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Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimers disease (AD) who do not possess an apolipoprotein E (ApoE)-«4 allele. Insulin has also been implicated in

Molecular enhancement of memory formation
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inhibitory that for the protein synthesis dependent long-term memory (7 day retention) to become asymptotic, a mini- CREB form (ApCREB2) that resembles human CREB2 and mouse ATF4 but is not homologous to Drosophila

Chemical studies on memory fixation in goldfish
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More significant is the fact that two structurally unrelated substances, both of which exert their antibiotic effect by selectively blocking protein synthesis, affect memory . Thus protein synthesis is further implicated as an obligatory step in memory formation

Memory CD4+T cells induce innate responses independently of pathogen
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The protective response is coincident with activation of CD11c+ cells but independent of the IFN-γ, TNF- and PAMP-recognition pathways. Similar IIC induction occurs when protein -specific memory cells recognize antigen in the absence of infec- tionThe formation of protein secondary structure especially the regions of β-sheets involves long- range interactions between amino acids. We propose a novel recurrent neural network architecture called segmented- memory recurrent neural network (SMRNN) and present

CREB: a mediator of long-term memory from mollusks to mammals
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Given the importance of a CREB-like protein in memory storage in Aplysia and the central role played by CAMP in learning in Drosophila, it was critical to determine whether CREBs function is important for memory in higher organ- isms short-term memory á LTM long-term memory á mACT median antenno-calycal tract á mb mushroom bodies á mlACT medio-lateral antenno- calycal tract á MTM mid-term memory á OA octopamine á PER proboscis extension response á PKA cAMP-dependent protein kinase A The requirement that protein must be synthesized in order to establish long-term memory , inferred from experiments3 with dissociated neurons in culture, is not necessarily inconsistent with the post-translational process that we describe

Protein synthesis and memory studied with anisomycin
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This paper considers a number of aspects of research using inhibitors of protein synthesis to determine the role of such synthesis in formation of long-term memory . The importance of aspects of the behavioral tasks is discussed, and the relative value of anisomycin and other Fear memory retrieval can lead to either reconsolidation (accompanied or not by strengthening of the memory trace) or extinction. Here, we show that non-reinforced retrieval of inhibitory avoidance (IA) conditioning can induce memory strengthening assessed in a

The effects of perinatal protein malnutrition on spatial learning and memory behaviour and brain-derived neurotrophic factor concentration in the brain tissue in
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This study aimed to investigate the effects of perinatal protein malnutrition on brain derived- neurotrophic factor (BDNF) concentration in brain tissue and spatial learning and memory performance in young rats. Nine pregnant Wistar rats were assigned into three groups. RatsThere is strong evidence that a restricted part of the chick forebrain, the IMM (formerly IMHV), stores information acquired through the learning process of visual imprinting. Twenty-four hours after imprinting training, a learning-specific increase in amount of myristoylated Neurology, 2 1166-1172 (1978). 19. Baddeley, A. D. Wilson, B. Autobiographical Memory (ed. Rubin, D.) (Cambridge Univ. Press, New York, 1986). 20 1 690-699 (1991). Role of guanylyl cyclase and cGMP dependent protein kinase in long term potentiation It is generally assumed that the formation of long-term memory involves cellular processes, which require the synthesis of new proteins. Evidence is drawn from studies with specific blockers of protein synthesis like puromycin, cycloheximide, or anisomycin applied to the The formation and maintenance of memories is one of the most intriguing functions of the brain. The human brain has the remarkable ability to store and retrieve past experiences for years and in some instances decades. Of late, extensive effort has been put into reducing

Identifying protein - protein interactions in biomedical literature using recurrent neural networks with long short-term memory
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In this paper, we propose a recurrent neural network model for identifying protein - protein interactions in biomedical literature. Experiments on two largest public benchmark datasets, AIMed and BioInfer, demonstrate that our approach significantly surpasses state-of-the-art2008; Kubik et al. 2007; Bramham et al. 2008). Here, we attempt to overview the Arc system spanning from reg- ulation of Arc RNA and protein , to functions in synaptic plasticity and adaptive behavior such as memory storage, and maladaptive behavior such as drug addiction -SOFTWARE SALES SERVICE-https://www.engpaper.net--